Spindle cell carcinoma11/2/2022 Repeat CT angiogram revealed worsening of the mediastinal mass with a new main pulmonary artery filling defect (image 3). Fecha de publicacin: 2020 Resumen: Spindle cell carcinoma (SCC) is a rare variant of squamous cell carcinoma characterized by elongated and pleomorphic. A transthoracic echocardiogram revealed a severely dilated right atrium and ventricle with significantly elevated pulmonary artery pressures, in addition to a large immobile echodense mass compromising much of the right ventricular outflow tract with extension into the pulmonary artery bifurcation. His troponin and proBNP were elevated at 9.93ng/mL and 4,943pg/mL, respectively. Two months later he was found to be acutely hypoxic and hypotensive at a routine radiation appointment and was subsequently sent to the emergency department. The tumor was deemed unresectable based on location and direct invasion of the right atrium and bilateral pulmonary arteries, and the patient was discharged home for chemoradiation with carboplatin and paclitaxel. Immunohistochemical analysis was positive only for SMARCA4 and negative for cytochrome AE1/AE3, PAN-K, CAM5.2, p40, MDM2, and PD-L1. A CT-guided biopsy demonstrated a highly anaplastic malignancy with uncertain histogenesis with features of both epithelioid and spindle cells (image 2). CT angiogram revealed a 6.0cm x 6.4cm irregular mediastinal mass invading the main pulmonary trunk as well as right and left pulmonary arteries causing obstruction with RV dysfunction (image 1). Histopathol- ogic grading in spindle cell soft tissue sarcomas. Initial vitals, lab work and physical examination were unremarkable. cellular sarcoma with sheets of small spindle cells, occasional storiform. Family and social history were negative, except for being a former smoker with a quit date 19 years prior. Medical history was significant for hypertension, hyperlipidemia, coronary artery disease status post CABG in 2011 and known prior subcentimeter pulmonary nodules. Licencia Creative Commons Atribución - No Comercial (CC - By-NC 4.CASE PRESENTATION: A 72-year-old male presented to an outside hospital with a one-week history of increasing dyspnea and chest pressure radiating to the left shoulder and back. Spindle cell carcinoma of the maxillary sinus with extension to the oral cavity"Autops Case Rep (São Paulo). Heterologous mesenchymal differentiation as bone, cartilage, and muscle is uncommon, especially malignant osteoid differentiation, as a handful of cases reported in the literature. It comprises 0.6-1.5 of all laryngeal cancers. 2020 10(3):e2020161ĭonohue Cornejo, A, Paes de Almeida, O, Sánchez-Romero, C y otros. Spindle cell squamous cell carcinoma of the larynx is a rare, aggressive variant of squamous cell carcinoma. We propose that SCC should be considered when examining a biphasic neoplasm with the aforementioned histological characteristics and markers.Īutops Case Rep (São Paulo). Thus, immunohistochemistry is a valuable resource to support the diagnosis. The diagnosis of SCC is challenging to the pathologist since its morphology can resemble a sarcoma. The immunohistochemistry panel used to determine the lineage of the tumor rendered the diagnosis of SCC. Expert Answers: Spindle cell carcinoma represents a rare variant of squamous cell carcinoma, characterized by spindled tumor cells that simulate a sarcoma but are epithelial Last Update: This is a question our experts keep getting from time to time. Histopathologically, the tumor was composed of spindle cells that were sarcomatous in appearance, with aberrant mitosis, along with a group of pleomorphic cells with a more epithelioid and hyperchromatic appearance on a stroma of densely vascularized fibrous tissue. Mucinous tubular and spindle cell carcinoma kidney with sarcomatoid and rhabdoid differentiation- A rare entity - IJPO- Print ISSN No: - 2394-6784 Online. The tomographic examination showed a hyperdense mass that infiltrated the orbital cavity, ethmoidal cells, middle and lower nasal concha, maxillary sinus, zygomatic arch, and mandibular ramus on the left side. Herein we present the case of an 82-year-old female with a polypoid, ulcerated, soft tissue mass located on the left side of the maxilla. Due to its rareness, and histological resemblance to various sarcomas, the diagnosis of this neoplasia is challenging. Spindle cell carcinoma (SCC) is a rare variant of squamous cell carcinoma characterized by elongated and pleomorphic epithelial cells that resemble a sarcoma. Spindle cell carcinoma of the maxillary sinus with extension to the oral cavity
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |